Strongyloides stercoralis & HIV: Ενδοπαρασιτική Δυναμική.  Συστηματική Ανασκόπηση.

Λιζάρδου, Αθηνά - Ευαγγελία

Strongyloides stercoralis & HIV: Endoparasitic Dynamics. Systimatic Review.

Πτυχιακή εργασία

Author

Λιζάρδου, Αθηνά - Ευαγγελία

Date

2024-07-22

Advisor

BARBOUNI, ANASTASIA

Πτυχιακή Έργασια (2.715Mb)

Keywords

Strongyloides stercoralis ; HIV ; Εντερικά βακτήρια ; Επιδημιολογία ; Εντερικά πρωτόζωα

Abstract

Ο σκοπός της πτυχιακής εργασίας είναι να προσεγγίσει και να αναλύσει την ενδοπαρασιστική παθογένεια, εστιάζοντας στο παράσιτο Strongyloides stercoralis σε άτομα θετικά στον HIV. Η εργασία θα πραγματοποιηθεί με συστηματική ανασκόπηση της υπάρχουσας βιβλιογραφίας για να κατανοήσει την επίδραση της συνύπαρξης των δύο παθογόνων στην πορεία της νόσου. Στόχος είναι να αξιολογηθούν οι κλινικές επιπτώσεις, οι αντιμικροβιακές θεραπευτικές προσεγγίσεις και οι πιθανοί παράγοντες που συνδέουν την ενδοπαρασιτική λοίμωξη με τον HIV.

Abstract

Introduction: Infection with the Human Immunodeficiency Virus (HIV) is one of the most significant challenges to global public health, affecting millions of people worldwide. The coexistence of other infections in HIV-positive individuals can worsen the course of the disease and complicate its management. One of these co-infections is Strongyloides stercoralis, a parasitic nematode that causes severe and potentially fatal complications, especially in immunocompromised individuals. Purpose: The purpose of this research is to examine the frequency and severity of infection by the parasite Strongyloides stercoralis in HIV-positive individuals, and to evaluate the consequences of this co-infection on the health and disease progression of these patients. Specifically, the research aims to document the epidemiology of both the infection and HIV, analyze the pathogenesis and clinical manifestations of both infections, and identify the diagnostic methods and challenges in diagnosing the infection. Additionally, the research aims to investigate therapeutic strategies and their effectiveness in immunocompromised patients. Methodology: A systematic review was conducted using the search engines PUBMED and MENDELEY following the PRISMA guidelines for the years 2012-2021. The articles are in English and focus on analyzing the prevalence of the infection. Results: This systematic review includes a total of 10 studies aimed at improving knowledge and attitudes regarding the parasite Strongyloides stercoralis in relation to HIV-positive individuals. Conclusions: In recent years, more research has been conducted on this parasite and its effects on patients. Timely diagnosis of both HIV and the parasite significantly contributes to their management. The integration of screening for Strongyloides stercoralis and the establishment of guidelines for clinicians is a crucial step in reducing the mortality of these individuals